insight you need into the newest certification exams for system administrators,
the 310-200 and the 310-202. It offers classroom-style training by one of the
best and well-known authors in the Solaris world, Bill Calkins. It will equip
you with vital knowledge for success on exam day plus it acts a reference guide
that will come in handy after the test. The content addresses all the new exam
objectives in detail and will show you how to apply this knowledge to real-world
scenarios.
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22125
Ann M. Berger (Editor), Russell K. Portenoy (Editor), David E. Weissman
(Editor), "Principles and Practice of Palliative Care and Supportive Oncology"
(2nd edition)
Lippincott Williams & Wilkins | ISBN 0781733243 | 2002 Year | PDB | 7,5 Mb |
1200 Pages[cut]
National Institutes of Health, Bethesda, MD. Revised edition of Principles and
Practice of Supportive Oncology, c1998. Brings together elements of palliative
care applicable to the professional caring for cancer patients and combines this
perspective with a detailed description of related therapies used in active
treatment.
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22126
Stanley B. Prusiner (Editor), "Prion Biology and Diseases"
Cold Spring Harbor Laboratory Press | ISBN 0879696931 | 2003 Year | PDF | 71 Mb
| 800 Pages[cut]
Prion-related diseases constitute a unique category of illnesses that can be
inherited, infectious, or sporadic. The ongoing saga of efforts to unravel the
pathogenesis of prion diseases is one of the most fascinating accounts in recent
medical science. This group of diseases seems to have dispelled two long-held
convictions: that nucleic acids are always needed to encode biologic information
transmitted from generation to generation, and that a protein of a given amino
acid sequence can give rise only to one tertiary structure of biologic
importance. Prion Biology and Diseases provides an authoritative review of the
work on prions. The book is an essential introduction for anyone embarking on
prion research and is also a useful reference for those already working in this
field.
The prion, or proteinaceous infectious particle, is thought to be responsible
for a wide range of diseases characterized clinically by dementia and
neuropathologically by neuronal loss, spongiform change, astrocytosis, and
varying degrees of amyloid deposition. Prion diseases in humans include
Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler
disease, and kuru; diseases in animals include scrapie and bovine spongiform
encephalopathy. The cause of these diseases is thought to be a conformational
change in a normal cellular protein, PrP(sup C), which is transformed into an
infectious protein called PrP(sup Sc) (the superscript Sc denotes scrapie).
PrP(sup Sc) does not differ from PrP(sup C) in its amino acid sequence or post-
translational modifications; unlike PrP(sup C), however, PrP(sup Sc) is
insoluble and resistant to proteinase K digestion, and it has a larger (beta)-
sheet content and a propensity to aggregate into fibrils.
Although prion diseases in humans have thus far been rare, they are among the
best-characterized "conformational diseases." Hence, the mechanisms of and
potential therapeutic approaches to prion diseases may be relevant to more
common conformational disorders, such as Alzheimer's disease (in which the
amyloid (beta)-peptide is deposited as amyloid), Parkinson's disease (involving
(alpha)-synuclein deposition in Lewy bodies), and the many neurodegenerative
conditions associated with increased CAG repeats (e.g., Huntington's disease).
Another reason for the importance of prion diseases is the recent reports of the
transmission of bovine spongiform encephalopathy to humans through contaminated
meat and bone meal, a topic that is well reviewed in this book. Evidence
suggests that bovine spongiform encephalopathy has crossed the species barrier
and now infects humans, resulting in new-variant Creutzfeldt-Jakob disease. It
is unclear whether these cases mark the beginning of a human epidemic in Europe
similar to that of bovine spongiform encephalopathy or whether the number of
cases will remain small, as occurred with iatrogenic Creutzfeldt-Jakob disease
after exposure to cadaveric growth hormone.
Many questions about prions remain unanswered, and for the most part, they are
thoroughly examined in this book. An important issue is the basis for prion
strains. There are many distinct isolates of prions, each associated with a
specific incubation time and with specific neuropathological and Western blot
features. If the protein-only hypothesis is correct, then each PrP(sup Sc)
strain has a different abnormal conformation. Another unanswered question
concerns "protein X." Prusiner and his colleagues have hypothesized that there
is a species-specific protein that facilitates the unfolding of PrP(sup C) and
its refolding into nascent PrP(sup Sc). Similar to the nucleic acid some suggest
is associated with the infectivity of prions, this protein remains unidentified.
The concept of protein X as a "pathological chaperone" is similar to the
proposed role of apolipoprotein E4 in Alzheimer's disease. An issue that also
needs to be resolved is the inability to develop synthetic or recombinant
PrP(sup Sc) that is infectious in vivo -- a crucial requirement for the final
proof of the protein-only hypothesis.
This book is a testament to the tremendous contributions of Prusiner and his
collaborators in the field of prion research. The majority of the 17 chapters
are coauthored by Prusiner or one or more of his collaborators. The information
is very well organized and consistent. Until the final questions about prions
are answered, however, this will continue to be an area of great controversy.
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It offers a comprehensive introduction to MapServer, the development platform
for integrating mapping technology into Internet applications. You'll learn how
to build and extend dynamic applications using popular languages like PHP, Perl,
and Python.
22127
Bill Kropla, "Beginning MapServer: Open Source GIS Development"
Apress | ISBN 1590594908 | 2005 Year | PDF | 10,28 Mb | 448 Pages[cut]
Password: www.AvaxHome.ru
22128
Barbara K. Given, "Teaching to the Brain's Natural Learning Systems"
Association for Supervision & Curriculum Deve | ISBN 0871205696 | 2002 Year |
linked PNG-files | 15,43 Mb | 163 Pages[cut]
Although the brain is the most complex entity in the universe, it can be studied
broadly as well as in great detail by focusing on five of its major systems:
emotional, social, cognitive, physical, and reflective. In Teaching to the
Brain's Natural Learning Systems, Barbara K. Given has cautiously investigated
brain structures and functions of these five systems and applied findings from
neurobiology to education without making leaps of judgment or unfounded claims.
Thus, this is the first book that translates neuroscience into an educational
framework for lesson planning and teaching.
The framework can serve as a mental model for an ongoing assessment of
youngsters' basic human needs to be themselves, to belong, to know, to do, and
to experiment and explore. It can also help teachers assess the roles they play
(mentor/model, collaborator, facilitator, coach, and talent scout) and the
personal/professional qualities they bring to the classroom (passion, vision,
intention, action, and reflection). This is a practical book for educators based
on current neurobiological insights into learning.
Password: www.AvaxHome.ru
22130
Lewis E. Braverman (Editor), Robert D. Utiger (Editor), Sidney H. Ingbar
(Editor), Sidney C. Werner (Editor), "Werner and Ingbar's the Thyroid: A
Fundamental and Clinical Text" (8th edition)
Lippincott Williams & Wilkins | ISBN 0397514069 | 1998 Year | PDB | 8,94 Mb |
1124 Pages[cut]
A revision of the work which has established the standards in thyroidology. This
comprehensive textbook has been designed to encompass both the basic and
clinical aspects of the entire subspecialty. It is comprehensive and well
organized with sections on normal thyroid anatomy and physiology, followed by
sections on thyroid function testing and specific thyroid disease. Reflecting
the rapid pace of changes in thyroidology, the Seventh Edition incorporates new
findings on cellular mechanisms, bone/mineral interactions, and management of
thyroid cancer.
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22132
Carl A. Davies, "Plane Truth: A Private Investigator's Story"
Algora Publishing | ISBN 1892941570 | 2001 Year | linked PNG-files | 13,87 Mb |
224 Pages[cut]
Boundless energy and boundless curiosity have enabled Davies to scratch out
little-known (and little heeded) facts surrounding the mysteries of our era's
most shocking airliner crashes. Adamantly refuting the popular notion of
"conspiracies", he posits an explanation based on the evidence, raising
questions about corporate and tribal loyalties, structural engineering, and
money and politics
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22133
Ernest E. Moore, David V. Feliciano, Kenneth L. Mattox, "Trauma" (5th edition)
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