This comprehensive reference provides an overdue review of the wide ranging facets of MAS simulation, including methodological and application-oriented guidelines. It reviews two decades of research in the intersection of MAS, simulation, and different application domains to provide scientists and developers with disciplined engineering approaches to modeling and developing MAS-based simulations. After providing an overview of the field’s history and basic principles it catalogs the various simulation engines for MAS. Complete with over 200 figures and formulas, the text devotes three sections to current and emerging approaches and applications.